Long-term depression of excitatory synaptic transmission and its relationship to long-term potentiation

@article{Artola1993LongtermDO,
  title={Long-term depression of excitatory synaptic transmission and its relationship to long-term potentiation},
  author={A. Artola and W. Singer},
  journal={Trends in Neurosciences},
  year={1993},
  volume={16},
  pages={480-487}
}
In many brain areas, including the cerebellar cortex, neocortex, hippocampus, striatum and nucleus accumbens, brief activation of an excitatory pathway can produce long-term depression (LTD) of synaptic transmission. In most preparations, induction of LTD has been shown to require a minimum level of postsynaptic depolarization and a rise in the intracellular Ca2+ concentration [Ca2+]i in the postsynaptic neurone. Thus, induction conditions resemble those described for the initiation of… Expand
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