Long-term depression of cortico-striatal synaptic transmission by DHPG depends on endocannabinoid release and nitric oxide synthesis.

@article{Sergeeva2007LongtermDO,
  title={Long-term depression of cortico-striatal synaptic transmission by DHPG depends on endocannabinoid release and nitric oxide synthesis.},
  author={Olga A. Sergeeva and Nanuli Doreulee and Aisa N. Chepkova and Thomas Kazmierczak and Helmut L. Haas},
  journal={The European journal of neuroscience},
  year={2007},
  volume={26 7},
  pages={
          1889-94
        }
}
In models of early stage Parkinson's disease (PD), motor deficits are accompanied by excessive activation of striatal glutamate receptors. Metabotropic glutamate group I receptors (mGluR I) play an important but not well-understood role in PD progression. In mouse brain slices, bath application of the mGluR I agonist (RS)-DHPG (3,5-dihydroxyphenylglycine, 100 microm for 20 min) caused a long-term depression of corticostriatal transmission (LTD(DHPG)), which was reversed by three mGluR I… CONTINUE READING

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