Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine

@article{Thomas2001LongtermDI,
  title={Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine},
  author={M. Thomas and C. Beurrier and A. Bonci and R. Malenka},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={1217-1223}
}
A compelling model of experience-dependent plasticity is the long-lasting sensitization to the locomotor stimulatory effects of drugs of abuse. Adaptations in the nucleus accumbens (NAc), a component of the mesolimbic dopamine system, are thought to contribute to this behavioral change. Here we examine excitatory synaptic transmission in NAc slices prepared from animals displaying sensitization 10–14 days after repeated in vivo cocaine exposure. The ratio of AMPA (α-amino-3-hydroxy-5-methyl-4… Expand
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