Long-term depression: a cellular basis for learning?

  title={Long-term depression: a cellular basis for learning?},
  author={K H Braunewell and Denise Manahan-Vaughan},
  journal={Reviews in the neurosciences},
  volume={12 2},
Long-term depression (LTD) comprises a persistent activity-dependent reduction in synaptic efficacy which typically occurs following repeated low frequency afferent stimulation. Hippocampal LTD has been a subject of particular interest due to the established role of the hippocampus in certain forms of information storage and retrieval. Recently, it was reported that LTD in the CA1 region may be associated with novelty acquisition in rats. CA1 LTD expression may also be increased in stressful… CONTINUE READING


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