Long-term decrease of CD4+CD45RA+ T cells and impaired primary immune response after post-traumatic splenectomy.

@article{Wolf1999LongtermDO,
  title={Long-term decrease of CD4+CD45RA+ T cells and impaired primary immune response after post-traumatic splenectomy.},
  author={Hermann Maximilian Wolf and Martha Marianne Eibl and Enrico Georgi and Aysen Samstag and Martin Spatz and Selman Uranues and R. Passl},
  journal={British journal of haematology},
  year={1999},
  volume={107 1},
  pages={55-68}
}
Congenital or acquired absence of the spleen and functional hyposplenism are associated with abnormalities of host defence such as an increased susceptibility to infection with encapsulated bacteria. The effects of the lack of the spleen on cell-mediated immunity are largely unknown. In the present study we have investigated peripheral blood lymphocyte subpopulations in healthy adults who had undergone splenectomy because of severe abdominal trauma > 4 years before the study. The results show a… CONTINUE READING