Long-term cyclosporin A nephrotoxicity in the rat. Evaluation of a morphological scoring system and of co-treatment with isradipine.

@article{Starklint1994LongtermCA,
  title={Long-term cyclosporin A nephrotoxicity in the rat. Evaluation of a morphological scoring system and of co-treatment with isradipine.},
  author={Henrik Starklint and Henriette Hansen and Michael A Kemp and Paul Peter Leyssac and Ejvind Kemp and Hans Herman Dieperink},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={1994},
  volume={102 5},
  pages={347-55}
}
Cyclosporin A (CyA) nephrotoxicity was examined in Spraque-Dawley rats given CyA (12.5 (n = 45) or 25 (n = 45) mg/kg/day perorally for 16 weeks. Control rats (n = 45) received CyA vehicle. All rats were given either isradipine (ISRA) 1 or 5 mg/kg/day orally, or isradipine vehicle. Fifteen rats died from interstitial pneumonia caused by Staphylococcus xylosus. A predefined morphological CyA nephrotoxicity scoring system, based on semiquantitative scores for basophilic tubules and for… CONTINUE READING
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