Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays.

@article{Schnecker2014LongtermCA,
  title={Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays.},
  author={Sven Sch{\"o}necker and U R S Kraushaar and Martina D{\"u}fer and Anika Sahr and Carmen H{\"a}rdtner and Elke Guenther and R. {\'A}lvarez-Sala Walther and Uwe Lendeckel and Winfried Barthlen and Peter Krippeit-Drews and Gisela Drews},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2014},
  volume={6 5},
  pages={540-4}
}
Extracellular recording of the glucose-induced electrical activity of mouse islets of Langerhans on microelectrode arrays (MEAs) is an innovative and powerful tool to address beta-cell (patho-)physiology. In a dual approach we tested whether this technique can detect concentration-dependent drug effects as well as characterize alterations in beta-cell activity during prolonged culture. First we established conditions that allow long-term investigation of beta-cell function by recording… CONTINUE READING
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