Long-term cultivation of Chinese hamster fibroblasts V-79 RJK under elevated temperature results in karyotype destabilization

Abstract

In this article, we show that long-term cultivation of Chinese hamster fibroblasts V-79 RJK at elevated temperature resulted in the selection of variants with genetic changes at the level of karyotype. Beginning at the first steps of thermoresistance (to a temperature of 40°C) selection, we identified a population of cells with changes in the karyotype… (More)
DOI: 10.1134/S1990519X15020078

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