Long-term creatine supplementation does not significantly affect clinical markers of health in athletes

@article{Kreider2004LongtermCS,
  title={Long-term creatine supplementation does not significantly affect clinical markers of health in athletes},
  author={Richard B. Kreider and Charles Melton and Chris J Rasmussen and Mike C Greenwood and Stacy L. Lancaster and Edward Cantler and Pervis Milnor and Anthony L. Almada},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={244},
  pages={95-104}
}
Creatine has been reported to be an effective ergogenic aid for athletes. However, concerns have been raised regarding the long-term safety of creatine supplementation. This study examined the effects of long-term creatine supplementation on a 69-item panel of serum, whole blood, and urinary markers of clinical health status in athletes. Over a 21-month period, 98 Division IA college football players were administered in an open label manner creatine or non-creatine containing supplements… Expand
Creatine supplementation does not affect clinical health markers in football players
TLDR
Property of CrM may be associated with an increase in CK activity, improving the efficiency for ATP resynthesis, a phenomenon indirectly confirmed by the decreasing tendency in uric acid concentration, and slightly influence glucoregulation in trained subjects. Expand
Effects of creatine supplementation on biomarkers of hepatic and renal function in young trained rats
TLDR
It was shown that the oral creatine supplementation promoted hepatic and renal function challenge in young rats submitted to moderate exercise training and showed the higher body weight at the end of the training protocol. Expand
Risk assessment of the potential side effects of long–term creatine supplementation in team sport athletes
TLDR
The data shows that low–dose supplementation with creatine monohydrate did not produce laboratory abnormalities for the majority of the parameters tested, and plasma concentrations of all clinical parameters did not alter significantly during the analyzed time frames of creatine supplementation. Expand
Long-term creatine supplementation is safe in aged patients with Parkinson disease.
TLDR
Although serum creatinine levels increased in Cr patients because of the degradation of Cr, all other markers of tubular or glomerular renal function, especially cystatin C, remained normal, indicating unaltered kidney function. Expand
Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet?
TLDR
A 12-week creatine supplementation protocol did not affect kidney function in resistance-trained healthy individuals consuming a high-protein diet; thus reinforcing the safety of this dietary supplement. Expand
Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial
TLDR
The decrease in cystatin C indicates that high-dose creatine supplementation over 3 months does not provoke any renal dysfunction in healthy males undergoing aerobic training, and the results suggest that moderate aerobic training per se may improve renal function. Expand
The Effect of Creatine Intake on Renal Function
TLDR
Creatine supplementation minimally impacts creatinine concentrations and renal function in young healthy adults and the increase in creatinin concentrations after long periods of creatine supplementation is extremely limited and unlikely to affect estimates of Creatine clearance and subsequent dosage adjustments. Expand
Safety of Creatine Supplementation in Active Adolescents and Youth: A Brief Review
TLDR
The purpose of this review was to highlight the limited number of studies available in adolescent populations and systematically discuss the topic of safety of creatine supplementation in a younger population. Expand
Creatine Supplementation
Creatine monohydrate is a dietary supplement that increases muscle performance in short-duration, high-intensity resistance exercises, which rely on the phosphocreatine shuttle for adenosineExpand
Effect of short-term creatine monohydrate supplementation on indirect markers of cellular damage in young soccer players
TLDR
It can be concluded that CrM loading probably have significant adverse effects on serum indirect markers of cellular damage, and more research will be needed to determine effect of the short and long-term Cr supplementation on the other indirect marker of cellular damages in the future. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 95 REFERENCES
Creatine supplementation and health variables: a retrospective study.
TLDR
The data suggest that long-term creatine supplementation does not result in adverse health effects and only two differences for creatinine and total protein were noted. Expand
Long-term oral creatine supplementation does not impair renal function in healthy athletes.
TLDR
There were no statistical differences between the control group and the creatine consumer group for plasma contents and urine excretion rates for creatinine, urea, and albumin, and clearances of these compounds did not differ between the two groups. Expand
Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function
TLDR
There is no apparent health risk associated with Cr supplementation to healthy people when it is ingested in quantities that have been scientifically proven to increase muscle Cr stores, and there is no obvious adverse effects of acute or more chronic Cr supplementation on the haematological indices measured, nor on hepatic, muscle, and renal function. Expand
Effect of short-term creatine supplementation on renal responses in men
TLDR
It was showed that short-term oral Cr supplementation does not appear to have any detrimental effect on the renal responses of healthy men. Expand
No effect of heavy resistance training and creatine supplementation on blood lipids.
TLDR
In healthy men, a 12-week heavy resistance training program, with or without creatine supplementation, did not significantly influence serum lipid profiles, subjective reports of body functioning, or serum creatinine concentrations. Expand
Muscle creatine loading in men.
TLDR
A rapid way to "creatine load" human skeletal muscle is to ingest 20 g of creatine for 6 days, which can be maintained by ingestion of 2 g/day thereafter, and the ingestion of 3 g creatine/day is in the long term likely to be as effective at raising tissue levels as this higher dose. Expand
Adverse Effects of Creatine Supplementation
TLDR
There is no evidence for deleterious effects in healthy individuals of creatine supplementation, but idiosyncratic effects may occur when large amounts of an exogenous substance containing an amino group are consumed, with the consequent increased load on the liver and kidneys. Expand
Short-term creatine supplementation does not alter the hormonal response to resistance training.
TLDR
It is concluded that short-term creatine supplementation does not alter the responses of growth hormone, testosterone, and cortisol to a single bout of heavy resistance training. Expand
Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults.
TLDR
It is concluded that oral creatine supplementation does not provide additional benefits for body composition, maximal dynamical strength, and dynamical and isometric endurances of healthy elderly subjects, whether or not it is associated with an effective strength training. Expand
Effects of creatine supplementation on muscle weakness in patients with rheumatoid arthritis.
TLDR
Although the skeletal muscle creatine content and muscle strength increased with creatine administration in some patients with RA, a clear clinical benefit could not be demonstrated for this treatment when the patients were considered as one group. Expand
...
1
2
3
4
5
...