Long-term creatine intake is beneficial to muscle performance during resistance training.

@article{Vandenberghe1997LongtermCI,
  title={Long-term creatine intake is beneficial to muscle performance during resistance training.},
  author={Katleen Vandenberghe and Marina Goris and Paul van Hecke and Marc van Leemputte and L. Vangerven and Peter Hespel},
  journal={Journal of applied physiology},
  year={1997},
  volume={83 6},
  pages={
          2055-63
        }
}
The effects of oral creatine supplementation on muscle phosphocreatine (PCr) concentration, muscle strength, and body composition were investigated in young female volunteers (n = 19) during 10 wk of resistance training (3 h/wk). Compared with placebo, 4 days of high-dose creatine intake (20 g/day) increased (P < 0.05) muscle PCr concentration by 6%. Thereafter, this increase was maintained during 10 wk of training associated with low-dose creatine intake (5 g/day). Compared with placebo… 

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References

SHOWING 1-10 OF 33 REFERENCES
Effect of oral creatine supplementation on muscle [PCr] and short-term maximum power output.
TLDR
Findings suggest that 3 d of oral Cr supplementation does not increase resting muscle PCr concentration and has no effect on performance during a single short-term maximal cycling task.
Caffeine counteracts the ergogenic action of muscle creatine loading.
TLDR
The data show that Cr supplementation elevates muscle PCr concentration and markedly improves performance during intense intermittent exercise, however, this ergogenic effect is completely eliminated by caffeine intake.
Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation.
TLDR
Seven male subjects performed repeated bouts of high-intensity exercise, on a cycle ergometer, before and after 6 d of creatine supplementation (20 g Cr H2O day-1) and there was no change in jump performance as a result of the creatine supplementation.
Creatine supplementation does not improve sprint performance in competitive swimmers.
TLDR
Creatine supplementation cannot be considered as an ergogenic aid for sprint performance in highly trained swimmers although adenine nucleotide degradation may be reduced during sprint exercise after 5 d of creatine ingestion.
Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis.
TLDR
The data suggest that a dietary-induced increase in muscle total Cr concentration can increase PCr resynthesis during the 2nd min of recovery from intense contraction.
Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man.
TLDR
Investigation of the influence of oral creatine supplementation on skeletal muscle isokinetic torque and the accumulation of plasma ammonia and blood lactate during five bouts of maximal exercise found muscle peak torque production was greater and plasma ammonia accumulation was lower during and after exercise after creatine ingestion.
Effect of oral creatine supplementation on respiratory gas exchange and blood lactate accumulation during steady-state incremental treadmill exercise and recovery in man.
TLDR
The results showed no measurable effect of creatine supplementation on respiratory gas exchange and blood lactate concentrations during either incremental submaximal exercise or recovery, which suggests that creatine supplementation does not influence substrate utilization during and after this type of exercise.
Effect of oral creatine supplementation on power output and fatigue during bicycle ergometry.
TLDR
It is suggested that oral creatine supplementation does not positively affect power output or fatigue during continuous high-intensity bicycle exercise in untrained men.
Muscle creatine loading in men.
TLDR
A rapid way to "creatine load" human skeletal muscle is to ingest 20 g of creatine for 6 days, which can be maintained by ingestion of 2 g/day thereafter, and the ingestion of 3 g creatine/day is in the long term likely to be as effective at raising tissue levels as this higher dose.
Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans.
TLDR
The results suggest that improvements in performance were mediated via improved ATP resynthesis as a consequence of increased PCr availability in type II fibers.
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