Long-term control of central nervous system leukaemia.

@article{Gribbin1977LongtermCO,
  title={Long-term control of central nervous system leukaemia.},
  author={Moira Gribbin and R. M. Hardisty and J. M. Chessells},
  journal={Archives of disease in childhood},
  year={1977},
  volume={52 9},
  pages={673-8}
}
Seventy-four children with acute lymphoblastic leukaemia had one or more episodes of central nervous system (CNS) leukaemia. 5 children had CNS involvement at diagnosis; 4 survived for less than one year. In 35 children who had not had a previous bone marrow relapse on treatment and who received combination chemotherapy, the median duration of haematological remission from the time of first CNS relapse was almost 3 years. 5 children received full dose (2400 rads) craniospinal irradiation after… CONTINUE READING
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Treatment of acute lymphoblastic leukaemia: effect of 'prophylactic' therapy against central nervous system leukemia

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Treatment of acute lymphoblastic leukaemia: comparison of immunotherapy (BCG), intermittent methotrexate, and no therapy after a five-month intensive cytotoxic regimen (Concord Trial)

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