Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation.

@article{Htter2009LongtermCO,
  title={Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation.},
  author={Gero H{\"u}tter and Daniel Nowak and Maximilian Mossner and Susanne Ganepola and Arne M{\"u}ssig and Kristina Allers and Thomas Schneider and J{\"o}rg Hofmann and Claudia K{\"u}cherer and Olga Blau and Igor Wolfgang Blau and Wolf-Karsten Hofmann and Eckhard Thiel},
  journal={The New England journal of medicine},
  year={2009},
  volume={360 7},
  pages={
          692-8
        }
}
Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and… 

Figures from this paper

Shift of HIV tropism in stem-cell transplantation with CCR5 Delta32 mutation.
To the Editor: Infection with the human immunodeficiency virus (HIV) requires entry into target cells by binding of the viral envelope to the CD4 receptor and to either the chemokine (C-C motif)
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