Long-term consequences of uninephrectomy in male and female rats.

@article{RodrguezGmez2012LongtermCO,
  title={Long-term consequences of uninephrectomy in male and female rats.},
  author={Isabel Rodr{\'i}guez-G{\'o}mez and Rosemary Wangensteen and Roc{\'i}o P{\'e}rez-Abud and Andr{\'e}s J. Quesada and Raimundo Garc{\'i}a Del Moral and A Osuna and Francisco O'Valle and Juan de Dios Luna and F{\'e}lix Vargas},
  journal={Hypertension},
  year={2012},
  volume={60 6},
  pages={1458-63}
}
We investigated the effects of uninephrectomy (UNX) in 6-week-old male and female rats on blood pressure (BP), renal sodium handling, salt sensitivity, oxidative stress, and renal injury over 18 months postsurgery, studying control sham-operated and UNX-operated rats at 6, 12, and 18 months postsurgery, evaluating their renal sodium handling, BP, urinary isoprostanes, N-acetyl-β-D-glucosaminidase, and proteinuria before and after a 2-week high-salt intake period. At 18 months, plasma variables… CONTINUE READING

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