Long term consequences of oxygen therapy in the neonatal period.

  title={Long term consequences of oxygen therapy in the neonatal period.},
  author={Alan Hall Jobe and Suhas G. Kallapur},
  journal={Seminars in fetal & neonatal medicine},
  volume={15 4},
Preterm and term infants are frequently exposed to high concentrations of oxygen for prolonged periods. In experimental models, high and prolonged oxygen exposures cause delayed alveolar septation and a bronchopulmonary dysplasia phenotype. Often, however, the oxygen exposure is tolerated in that the infants recover without severe lung or systemic injury. Multiple exposures change oxygen sensitivity in adult and newborn animals. Examples are antenatal corticosteroids, inflammatory mediators or… CONTINUE READING
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