Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease

@inproceedings{Beck2017LongtermCO,
  title={Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease},
  author={Susanne C Beck and Yuxi Feng and Vithiyanjali Sothilingam and Marina Garcia Garrido and Naoyuki Tanimoto and Niyazi Acar and Shenliang Shan and Britta Seebauer and Wolfgang J Berger and Hans Peter Hammes and Mathias Wolfgang Seeliger},
  booktitle={PloS one},
  year={2017}
}
Loss of Norrin signalling due to mutations in the Norrie disease pseudoglioma gene causes severe vascular defects in the retina, leading to visual impairment and ultimately blindness. While the emphasis of experimental work so far was on the developmental period, we focus here on disease mechanisms that induce progression into severe adult disease. The goal of this study was the comprehensive analysis of the long-term effects of the absence of Norrin on vascular homeostasis and retinal function… CONTINUE READING
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