Long-term consequences of a prolonged febrile seizure in a dual pathology model

@article{Gibbs2011LongtermCO,
  title={Long-term consequences of a prolonged febrile seizure in a dual pathology model},
  author={Steve A Gibbs and Bidisha Chattopadhyaya and S{\'e}bastien Desgent and Patricia N Awad and Lionel Carmant},
  journal={Neurobiology of Disease},
  year={2011},
  volume={43},
  pages={312-321}
}
Clinical evidence suggests that febrile status epilepticus (SE) in children can lead to acute hippocampal injury and subsequent temporal lobe epilepsy. The contribution of febrile SE to the mechanisms underlying temporal lobe epilepsy are however poorly understood. A rat model of temporal lobe epilepsy following hyperthermic SE was previously established in our laboratory, wherein a focal cortical lesion induced at postnatal day 1 (P1), followed by a hyperthermic SE (more than 30 min) at P10… CONTINUE READING
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Atypical Febrile Seizures, Mesial Temporal Lobe Epilepsy, and Dual Pathology

  • Epilepsy research and treatment
  • 2012
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