Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model.

@article{Semmler2007LongtermCI,
  title={Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model.},
  author={Alexander Semmler and Christian Frisch and Thomas Debeir and Mutiah Ramanathan and Thorsten Okulla and Thomas Klockgether and Michael T Heneka},
  journal={Experimental neurology},
  year={2007},
  volume={204 2},
  pages={733-40}
}
Sepsis is a disease with a high and growing prevalence worldwide. Most studies on sepsis up to date have been focused on reduction of short-term mortality. This study investigates cognitive and neuroanatomical long-term consequences of sepsis in a rat model. Sepsis was induced in male Wistar rats weighing 250-300 g by an i.p. injection of bacterial lipopolysaccharide (LPS, 10 mg/kg). Three months after complete recovery from sepsis, animals showed memory deficits in the radial maze and changes… CONTINUE READING

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