Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning.

@article{Joosen2009LongtermCD,
  title={Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning.},
  author={Marloes J A Joosen and Edwin Jousma and Tom M. van den Boom and Willem C. Kuijpers and August B. Smit and Paul John Lucassen and Herman P M van Helden},
  journal={Neurotoxicology},
  year={2009},
  volume={30 1},
  pages={
          72-80
        }
}
To date, treatment of organophosphate (OP) poisoning shows several shortcomings, and OP-victims might suffer from lasting cognitive deficits and sleep-wake disturbances. In the present study, long-term effects of soman poisoning on learning ability, memory and neurogenesis were investigated in rats, treated with the anticholinergic atropine and the oxime HI-6 for reactivation of soman-inhibited acetylcholinesterase. We also investigated whether sub-chronic treatment with the reported… CONTINUE READING
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