Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning.

@article{Joosen2009LongtermCD,
  title={Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning.},
  author={Marloes J. A. Joosen and Edwin Jousma and Tom M van den Boom and Willem C. Kuijpers and August Benjamin Smit and Paul J. Lucassen and Herman P. M. van Helden},
  journal={Neurotoxicology},
  year={2009},
  volume={30 1},
  pages={
          72-80
        }
}

Potential pharmacological strategies for the improved treatment of organophosphate-induced neurotoxicity.

TLDR
These neuroprotective strategies may prevent secondary neuronal damage in both early and late stages of OP poisoning, and thus may be a beneficial approach to treating the neuropsychological and neuronal impairments resulting from OP toxicity.

Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure

TLDR
The results suggest that alpha-linolenic acid induces a long-lasting neurorestorative effect that involves activation of mTORC1 possibly via a BDNF-TrkB-mediated mechanism.

Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?

TLDR
Combined treatment of obidoxime and physostigmine shortened the duration of seizures, if present, from up to 80 min to ~10–15 min, and treatment of OP poisoning with a carbamate, such as physostIGmine should be carefully re-evaluated.

Long‐term neuropathological and behavioral impairments after exposure to nerve agents

TLDR
The basolateral amygdala (BLA), which appears to be a key site for seizure initiation upon exposure, suffers severe neuronal loss; however, GABAergic BLA interneurons display a delayed death, perhaps providing a window of opportunity for rescuing intervention.

(-)-Phenserine Attenuates Soman-Induced Neuropathology

TLDR
It is demonstrated that (-)-phenserine protects neurons against soman-induced neuronal cell death in rats when administered either as a pretreatment or post-treatment paradigm, improves motoric movement in soman -exposed animals and reduces mortality when given as a Pretreatment.

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