Long-term coenzyme Q10 therapy for a mitochondrial encephalomyopathy with cytochrome c oxidase deficiency: a 31P NMR study.

@article{Nishikawa1989LongtermCQ,
  title={Long-term coenzyme Q10 therapy for a mitochondrial encephalomyopathy with cytochrome c oxidase deficiency: a 31P NMR study.},
  author={Yasumasa Nishikawa and Makoto Takahashi and Shiro Yorifuji and Yusaku Nakamura and Shigeru Ueno and Seiichiro Tarui and Takuyo Kozuka and Tsunehiko Nishimura},
  journal={Neurology},
  year={1989},
  volume={39 3},
  pages={399-403}
}
For 2 years we administered high doses of coenzyme Q10 (CoQ) to a patient having mitochondrial encephalomyopathy with cytochrome c oxidase deficiency. Abnormal elevation of the serum lactate per pyruvate ratio and the increased concentration of serum lactate plus pyruvate induced by exercise decreased with CoQ treatment. This therapeutic effect continued for 2 years. 31P nuclear magnetic resonance spectroscopy showed acceleration of the postexercise recovery of the ratio of phosphocreatine to… CONTINUE READING
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