Long-term clinical efficacy of grass-pollen immunotherapy.
@article{Durham1999LongtermCE, title={Long-term clinical efficacy of grass-pollen immunotherapy.}, author={Stephen R. Durham and Samantha M. Walker and Eva M Varga and Mikila R Jacobson and F O'brien and W Noble and Stephen J Till and Qutayba Hamid and Kayhan T. Nouri-Aria}, journal={The New England journal of medicine}, year={1999}, volume={341 7}, pages={ 468-75 } }
BACKGROUND
Pollen immunotherapy is effective in selected patients with IgE-mediated seasonal allergic rhinitis, although it is questionable whether there is long-term benefit after the discontinuation of treatment.
METHODS
We conducted a randomized, double-blind, placebo-controlled trial of the discontinuation of immunotherapy for grass-pollen allergy in patients in whom three to four years of this treatment had previously been shown to be effective. During the three years of this trial…
1,225 Citations
Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies.
- Medicine, BiologyThe Journal of allergy and clinical immunology
- 2011
Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: A randomized controlled trial.
- MedicineThe Journal of allergy and clinical immunology
- 2016
Long-term clinical efficacy in grass pollen-induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet.
- Medicine, PsychologyThe Journal of allergy and clinical immunology
- 2010
Additional benefit of a third year of specific grass pollen allergoid immunotherapy in patients with seasonal allergic rhinitis.
- MedicineEuropean annals of allergy and clinical immunology
- 2007
Pre-seasonal short-term immunotherapy with the high-dose, hypoallergenic allergen preparation Allergovit has been shown to be efficacious and safe and a course of three years of 6-grass pollen SIT further improves allergic symptoms, quality of life and reduces the need for anti-allergic medication.
Long-term allergen-specific immunotherapy correlates with long-term allergen-specific immunological tolerance
- MedicineAdvances in therapy
- 2008
Long-term SIT therapy correlates with long-term, allergen-specific, acquired immunological tolerance, and there was significant difference between the groups (P<0.05).
Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity.
- Medicine, BiologyThe Journal of allergy and clinical immunology
- 2008
Long-term Efficacy of House Dust Mite Immunotherapy in Bronchial Asthma: A 15-year Follow-up Study
- Medicine
- 2005
The use of immunotherapy resulted in a statistically significant improvement in both global symptom scores and FEV1 in patients receiving immunotherapy when compared with those in the control group who did not receive immunotherapy.
Twenty years’ observation of subcutaneous pollen allergoid immunotherapy efficacy in adults
- MedicinePostepy dermatologii i alergologii
- 2017
SIT had a long-term effect that did not depend significantly on the duration of immunotherapy against pollen, and this study cohort, patients were prospectively observed for 20 years to determine its effectiveness.
Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis.
- MedicineThe Journal of allergy and clinical immunology
- 2006
Clinical efficacy of microencapsulated timothy grass pollen extract in grass-allergic individuals.
- MedicineAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
- 2004
References
SHOWING 1-10 OF 83 REFERENCES
Grass pollen immunotherapy: efficacy and safety during a 4‐year follow‐up study
- MedicineAllergy
- 1995
It is shown that efficacy was maintained throughout the 3–4‐year study period, and clinical improvement was accompanied by a sustained and marked decrease in immediate conjunctival allergen sensitivity and a further significant decrease in the size of the allergenic‐induced late cutaneous response.
Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by antiallergic drugs.
- MedicineBMJ
- 1991
Immunotherapy is effective in patients with severe summer hay fever, but immediate anaphylactic reactions limit its use to specialised centres.
Randomised controlled trial of local allergoid immunotherapy on allergic inflammation in mite-induced rhinoconjunctivitis
- MedicineThe Lancet
- 1998
A double-blind study of the discontinuation of ragweed immunotherapy.
- MedicineThe Journal of allergy and clinical immunology
- 1997
Grass pollen immunotherapy: a single year double-blind, placebo-controlled study in patients with grass pollen-induced asthma and rhinitis.
- MedicineThe Journal of allergy and clinical immunology
- 1984
Does the effect of immunotherapy last after termination of treatment?
- MedicineAllergy
- 1988
The clinical effect was still present more than 6 years after termination of treatment, with no significant difference between groups, and some in vitro parameters tended to return to pretreatment level.
Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.
- Biology, MedicineThe Journal of clinical investigation
- 1993
Findings indicate that immunotherapy is associated with suppression of allergen-induced CD4+ T lymphocyte infiltration, but among the cells that are recruited, there is upregulation of CD25 and HLA-DR.
A double‐blind, placebo‐controlled study of immunotherapy with grass‐pollen extract Alutard SQ during a 3–year period with initial rush immunotherapy
- MedicineAllergy
- 1996
The efficacy and safety of immunotherapy with grass pollen make it possible to consider this treatment fundamental in patients with asthma and/or monosensitized allergic rhinitis, and there was no relationship between clinical improvement and the range of specific immunoglobulin E values.
Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma.
- Medicine, BiologyThe Journal of allergy and clinical immunology
- 1996
A controlled trial of immunotherapy for asthma in allergic children.
- MedicineThe New England journal of medicine
- 1997
Immunotherapy with injections of allergens for over two years was of no discernible benefit in allergic children with perennial asthma who were receiving appropriate medical treatment.