Long-term clinical efficacy of grass-pollen immunotherapy.

  title={Long-term clinical efficacy of grass-pollen immunotherapy.},
  author={S. Durham and S. Walker and E. Varga and M. Jacobson and F. O'Brien and W. Noble and S. Till and Q. Hamid and K. Nouri-Aria},
  journal={The New England journal of medicine},
  volume={341 7},
  • S. Durham, S. Walker, +6 authors K. Nouri-Aria
  • Published 1999
  • Medicine
  • The New England journal of medicine
  • BACKGROUND Pollen immunotherapy is effective in selected patients with IgE-mediated seasonal allergic rhinitis, although it is questionable whether there is long-term benefit after the discontinuation of treatment. METHODS We conducted a randomized, double-blind, placebo-controlled trial of the discontinuation of immunotherapy for grass-pollen allergy in patients in whom three to four years of this treatment had previously been shown to be effective. During the three years of this trial… CONTINUE READING
    1,195 Citations
    Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies.
    • 257
    • PDF
    Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: A randomized controlled trial.
    • 28
    Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity.
    • 278
    • PDF
    Twenty years’ observation of subcutaneous pollen allergoid immunotherapy efficacy in adults
    • 2
    • PDF
    Clinical efficacy of microencapsulated timothy grass pollen extract in grass-allergic individuals.
    • 36


    A double-blind study of the discontinuation of ragweed immunotherapy.
    • 74
    A controlled trial of immunotherapy for asthma in allergic children.
    • 294