Long-term clinical effect of nilvadipine in patients with chronic heart failure: A double-blind placebo-controlled study

@article{Hori1994LongtermCE,
  title={Long-term clinical effect of nilvadipine in patients with chronic heart failure: A double-blind placebo-controlled study},
  author={Masatsugu Hori and Hideyuki Sato and Michiko Karita and Kazuhisa Kodama and Noritake Hoki and Tohru Hayashi and Masashi Naka and Shinsuke Nanto and Yoshio Yamada and Takenobu Kamada},
  journal={Heart and Vessels},
  year={1994},
  volume={9},
  pages={249-253}
}
The long-term effect of calcium channel blockers on chronic heart failure is disappointing, probably because of reflex sympathetic activation through arterial vasodilation. However, nilvadipine may be beneficial for treatment of chronic heart failure since this drug has minimal effects on sympathetic activation. In this study, the effects of 12-week administration of nilvadipine or placebo on symptoms of heart failure and cardiac function were investigated in 23 patients with mild-to-moderate… CONTINUE READING