Long-term clearance of liquid and protein from the lungs of unanesthetized sheep.

@article{Matthay1985LongtermCO,
  title={Long-term clearance of liquid and protein from the lungs of unanesthetized sheep.},
  author={Michael A. Matthay and Yves Berthiaume and Norman C. Staub},
  journal={Journal of applied physiology},
  year={1985},
  volume={59 3},
  pages={928-34}
}
We measured the removal of 100 ml of autologous serum from the air spaces and lungs of unanesthetized, spontaneously breathing sheep at 4, 12, and 24 h. In the first 4 h, there was a rapid clearance of the liquid volume (8.3%/h), similar to our results in anesthetized ventilated sheep (Matthay et al., J. Appl. Physiol. 53: 96-104, 1982). However, liquid removal progressively slowed to 3.3 and 1.4%/h at 12 and 24 h, respectively. In contrast, protein clearance (as measured by 125I-albumin… CONTINUE READING

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