Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor.

  title={Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor.},
  author={Terrence Deak and Kien T. Nguyen and Crystal S Cotter and Monika Fleshner and Linda R. Watkins and Steven F. Maier and Robert L Spencer},
  journal={Brain research},
  volume={847 2},
Stressors produce rapid activation of the hypothalamic-pituitary-adrenal axis, which typically resolves within 60-90 min following termination of the stressor. In addition, some stressors such as inescapable tailshock (IS) also produce elevated basal levels of corticosterone (CORT), and reduced serum levels of corticosteroid binding globulin (CBG). The elevated basal levels of CORT produced by IS are only observed at the trough of the circadian rhythm of CORT secretion, and are sustained for 2… CONTINUE READING


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