Long-term changes in insulin action and insulin secretion associated with gain, loss, regain and maintenance of body weight

@article{Weyer2000LongtermCI,
  title={Long-term changes in insulin action and insulin secretion associated with gain, loss, regain and maintenance of body weight},
  author={Christian Weyer and Kevin Hanson and Clifton Bogardus and Richard E. Pratley},
  journal={Diabetologia},
  year={2000},
  volume={43},
  pages={36-46}
}
Aims/hypothesis. We aimed to quantify changes in insulin action and insulin secretion associated with long-term gain, loss, regain, and maintenance of body weight in subjects with normal (NGT) or impaired (IGT) glucose tolerance.¶Methods. Insulin action (hyperinsulinaemic clamp) and insulin secretion (intravenous glucose challenge) were measured longitudinally in 209 Pima Indians [body weight 94.4 ± 22.8 kg (means ± SD) 89 women/120 men, 151 NGT/58 IGT], who either lost (n = 110) or gained (n… CONTINUE READING

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References

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Showing 1-10 of 49 references

Toward physiological understanding of glucose tolerance: minimal model approach

  • RN Bergman
  • Diabetes
  • 1989
Highly Influential
5 Excerpts

Report of the expert committee on the diagnosis and classification of diabetes mellitus ( Committee Report )

  • RF Goldman, ER Buskirk
  • Diabetes Care
  • 1998

The determinants of glycemic responses to diet restriction and weight loss in obesity and NIDDM

  • TP Marcovic, AB Jenkins, LV Campbell, SM Furler, EW Kraegen, DJ Chisholm
  • Diabetes Care
  • 1998
2 Excerpts

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