Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat.

@article{Stolp2005LongtermCI,
  title={Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat.},
  author={Helen Bronwyn Stolp and Katarzyna Magdalena Dziegielewska and Carl Joakim Ek and Ann M Potter and Norman R Saunders},
  journal={The European journal of neuroscience},
  year={2005},
  volume={22 11},
  pages={
          2805-16
        }
}
Epidemiological evidence in human fetuses links inflammation during development with white matter damage. Breakdown of the blood-brain barrier has been proposed as a possible mechanism. This was investigated in the present study by inducing a prolonged inflammatory response in newborn rats, with intraperitoneal injections of lipopolysaccharide (LPS; 0.2 mg/kg) given at postnatal (P) day 0, P2, P4, P6 and P8. An acute phase response was present over the whole period of injections. Changes in… CONTINUE READING
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