Long term changes in augmentation, potentiation, and depression of transmitter release as a function of repeated synaptic activity at the frog neuromuscular junction.

@article{Magleby1976LongTC,
  title={Long term changes in augmentation, potentiation, and depression of transmitter release as a function of repeated synaptic activity at the frog neuromuscular junction.},
  author={Karl L. Magleby and Janet E. Zengel},
  journal={The Journal of physiology},
  year={1976},
  volume={257 2},
  pages={
          471-94
        }
}
1. End-plate potentials (e.p.p.s) were recorded from frog neuromuscular junctions under conditions of low quantal content to study the long-term effects of repeated synaptic activity on transmitter release. 2. The nerve terminal was presented with 30-100 successive conditioning-testing trials applied once every 7-10 min over a 4-16 hr perod. Each conditioning-testing trial consisted of a 200-600 impulse conditioning train followed by a series of testing impulses. The magnitudes and time… CONTINUE READING
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