Long-term change in synaptic transmission in CA3 circuits followed by spontaneous rhythmic activity in rat hippocampal slices.

@article{Nakashima2001LongtermCI,
  title={Long-term change in synaptic transmission in CA3 circuits followed by spontaneous rhythmic activity in rat hippocampal slices.},
  author={Kenichi Nakashima and Hideaki Hayashi and Okiyasu Shimizu and Satoru Ishizuka},
  journal={Neuroscience research},
  year={2001},
  volume={40 4},
  pages={325-36}
}
The relevance of long-term potentiation (LTP) at excitatory synapses in CA3 circuits to generation of spontaneous epileptiform bursts in CA3 was investigated using rat hippocampal slices. CA3 pyramidal cells were antidromically stimulated through Schaffer collaterals. Evoked field potentials were extracellularly recorded from the stratum pyramidale and the stratum radiatum in CA3. Therefore, field potentials reflecting recurrent excitatory post-synaptic potentials (EPSPs) and inhibitory post… CONTINUE READING