Long-term cell-mediated protein release from calcium phosphate ceramics.

  title={Long-term cell-mediated protein release from calcium phosphate ceramics.},
  author={Ellen Wernike and Willy Hofstetter and Yuelian Liu and Gang Wu and Hans-J{\"o}rg Sebald and Daniel Wismeijer and Ernst Bruno Hunziker and Klaus-Arno Siebenrock and Frank Michael Klenke},
  journal={Journal of biomedical materials research. Part A},
  volume={92 2},
Efficient delivery of growth factors from carrier biomaterials depends critically on the release kinetics of the proteins that constitute the carrier. Immobilizing growth factors to calcium phosphate ceramics has been attempted by direct adsorption and usually resulted in a rapid and passive release of the superficially adherent proteins. The insufficient retention of growth factors limited their bioavailability and their efficacy in the treatment of bone regeneration. In this study, a… CONTINUE READING
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