Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction.

@article{Kompa2008LongtermBN,
  title={Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction.},
  author={Andrew R. Kompa and Fiona See and Dion A Lewis and Anastasia Adrahtas and D. Marianne Cantwell and Bing Hui Wang and Henry Krum},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={325 3},
  pages={741-50}
}
p38 mitogen-activated protein kinase (p38 MAPK) inhibition exerts beneficial effects on left ventricular (LV) remodeling and dysfunction. p38 MAPK activity is transiently increased soon after myocardial infarction (MI), suggesting brief inhibition may afford the same benefit as long-term inhibition. We examined chronic 12-week p38 MAPK inhibition compared with short-term (7-day) inhibition, and then we discontinued inhibition after MI. Post-MI rats at day 7 received either vehicle, 4-[4-(4… CONTINUE READING

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