Long-term behavioural and neuroendocrine changes in Roman high-(RHA/Verh) and low-(RLA-Verh) avoidance rats following neonatal handling.

@article{Steimer1998LongtermBA,
  title={Long-term behavioural and neuroendocrine changes in Roman high-(RHA/Verh) and low-(RLA-Verh) avoidance rats following neonatal handling.},
  author={Thierry Steimer and Rosa Mar{\'i}a Escorihuela and Alberto Fern{\'a}ndez-Teruel and Peter Driscoll},
  journal={International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience},
  year={1998},
  volume={16 3-4},
  pages={165-74}
}
Roman high-(RHA/Verh) and low-(RLA/Verh) avoidance rats, originally selected and bred for rapid vs poor acquisition of a two-way active avoidance response, differ in emotional reactivity and coping style. These differences are associated with particular neuroendocrine and neurochemical characteristics. New data are presented here to show that the behavioural changes specifically induced by neonatal handling, i.e. decreased emotional reactivity, are associated with marked changes in the… CONTINUE READING

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These results suggest that psychogenetically selected lines such as RHA / RLA rats are suitable animal models to investigate interactions between genes and the environment in determining individual sensitivity to stress and coping styles , as well as potential vulnerability ( or resistance ) to the development of maladaptive syndromes similar to anxiety and mood disorders in humans .
These results suggest that psychogenetically selected lines such as RHA / RLA rats are suitable animal models to investigate interactions between genes and the environment in determining individual sensitivity to stress and coping styles , as well as potential vulnerability ( or resistance ) to the development of maladaptive syndromes similar to anxiety and mood disorders in humans .
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