Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism.

@article{Harris2003LongtermBM,
  title={Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism.},
  author={Laura Wiseman Harris and Trevor Sharp and Jane Gartlon and Declan N. C. Jones and Paul J. Harrison},
  journal={The European journal of neuroscience},
  year={2003},
  volume={18 6},
  pages={1706-10}
}
Brief N-methyl-D-aspartate (NMDA) receptor blockade in neonatal rats has been reported to increase neuronal apoptosis. We replicated this finding using MK-801 (0.5 mg/kg) administered twice on postnatal day 7, and then studied the long-term consequences. In adulthood, treated rats showed reduced volume and neuronal number within the hippocampus, and altered hippocampal NMDA receptor (NR1 subunit) expression. Synaptophysin mRNA was decreased in the thalamus (laterodorsal nucleus). Adult MK-801… CONTINUE READING
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