Long-term behavioral and pharmacodynamic effects of delta-9-tetrahydrocannabinol in female rats depend on ovarian hormone status.

@article{Winsauer2011LongtermBA,
  title={Long-term behavioral and pharmacodynamic effects of delta-9-tetrahydrocannabinol in female rats depend on ovarian hormone status.},
  author={Peter John Winsauer and Jill M. Daniel and Catalin M. Filipeanu and Stuart T Leonard and Jerielle L Hulst and Shaefali P Rodgers and Caroline L Lassen-Greene and Jessie L. Sutton},
  journal={Addiction biology},
  year={2011},
  volume={16 1},
  pages={64-81}
}
Abuse of Δ⁹-THC by females during adolescence may produce long-term deficits in complex behavioral processes such as learning, and these deficits may be affected by the presence of ovarian hormones. To assess this possibility, 40 injections of saline or 5.6 mg/kg of Δ⁹-THC were administered i.p. daily during adolescence to gonadally intact or ovariectomized (OVX) female rats, yielding four treatment groups (intact/saline, intact/THC, OVX/saline, and OVX/ THC). Δ⁹-THC (0.56-10 mg/kg) was then re… CONTINUE READING