Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors.

@article{Haddjeri1998LongtermAT,
  title={Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors.},
  author={Nasser Haddjeri and Pierre Blier and Claude de Montigny},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 23},
  pages={10150-6}
}
We report here the first direct functional evidence of an increase in the tonic activation of postsynaptic 5-HT1A receptors by antidepressant treatments. Because 5-HT1A receptor activation hyperpolarizes and inhibits CA3 pyramidal neurons in the dorsal hippocampus, we determined, using in vivo extracellular recording, whether the selective 5-HT1A receptor antagonist WAY 100635 could disinhibit these neurons. Unexpectedly, no disinhibition could be detected in controls. However, after long-term… CONTINUE READING
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