Long-term alterations in adiposity affect the expression of melanin-concentrating hormone and enkephalin but not proopiomelanocortin in the hypothalamus of ovariectomized ewes.

@article{Henry2000LongtermAI,
  title={Long-term alterations in adiposity affect the expression of melanin-concentrating hormone and enkephalin but not proopiomelanocortin in the hypothalamus of ovariectomized ewes.},
  author={Belinda A. Henry and Alan J. Tilbrook and Frank Rowland Dunshea and Alexandra Rao and Dominique Blache and G B Martin and I. J. Clarke},
  journal={Endocrinology},
  year={2000},
  volume={141 4},
  pages={1506-14}
}
We have developed a ruminant model to study long-term alterations in adiposity on the expression of appetite-regulating peptides in the hypothalamus. In this model endocrine and metabolic status are fully defined as well as body composition. The current study sought to define the effects of altered adiposity on the expression of genes for neuropeptide Y (NPY), POMC, enkephalin (ENK), and melanin-concentrating hormone (MCH). Ovariectomized ewes with high (60 +/- 1 kg) (FAT) or low (37 +/- 3 kg… CONTINUE READING
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