Long-term alpha-tocopherol supplementation is associated with lower serum vascular endothelial growth factor levels.


BACKGROUND We previously reported that daily supplementation with alpha-tocopherol reduced prostate cancer risk in a large, randomized trial, the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. One potential mechanism explaining this is that alpha-tocopherol inhibited tumor angiogenesis, an effect demonstrated in animal models. PATIENTS… (More)