Long-term allograft tolerance is characterized by the accumulation of B cells exhibiting an inhibited profile.

@article{Texier2011LongtermAT,
  title={Long-term allograft tolerance is characterized by the accumulation of B cells exhibiting an inhibited profile.},
  author={Laetitia Le Texier and Pam{\'e}la Th{\'e}bault and Am{\'e}lie Lavault and Claire Usal and Emmanuel M{\'e}rieau and Thibaut Quillard and B{\'e}atrice Charreau and J. P. Soulillou and Maria Cristina Cuturi and Sophie Brouard and Elise Chiffoleau},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2011},
  volume={11 3},
  pages={
          429-38
        }
}
Numerous reports have highlighted the central role of regulatory T cells in long-term allograft tolerance, but few studies have investigated the B-cell aspect. We analyzed the B-cell response in a rat model of long-term cardiac allograft tolerance induced by a short-term immunosuppression. We observed that tolerated allografts are infiltrated by numerous B cells organized in germinal centers that are strongly regulated in their IgG alloantibody response. Moreover, alloantibodies from tolerant… CONTINUE READING
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