Long-term administration of salicylate enhances prestin expression in rat cochlea.

@article{Yang2009LongtermAO,
  title={Long-term administration of salicylate enhances prestin expression in rat cochlea.},
  author={Kun Yang and Zhi-wu Huang and Zhi-Qi Liu and Bo-kui Xiao and Jian-hua Peng},
  journal={International journal of audiology},
  year={2009},
  volume={48 1},
  pages={
          18-23
        }
}
Salicylate, a common drug frequently used long term in the clinic, is well known for causing reversible hearing loss and tinnitus. Our previous study, however, demonstrated that chronic administration of salicylate progressively raised the amplitude of distortion product of otoacoustic emissions (DPOAEs), which are mainly caused by (outer hair cell) OHC electromotility. How salicylate affects OHC electromotility to cause this paradoxical increase remains unclear. One possibility is that it… CONTINUE READING
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