Long-term administration of natural interferon-alpha in patients with chronic hepatitis C: relationship to serum RNA concentration, HCV-RNA genotypes, histological changes and hepatitis C virus.

@article{Kumada1996LongtermAO,
  title={Long-term administration of natural interferon-alpha in patients with chronic hepatitis C: relationship to serum RNA concentration, HCV-RNA genotypes, histological changes and hepatitis C virus.},
  author={Takashi Kumada and S. Hidaka Z. Hu H. Kato K. Nakano and Isao Takeda and Kimio Sugiyama and Tadahiro Osada and Seiki Kiriyama and Hidenori Toyoda and Takahiro Sasa and Minoru Shibata and Tsuneo Morishima and Itsuro Nakano and Yoshihide Fukuda and Yoshitane Kosaka and Yukihiko Tameda and Masanori Nakashima},
  journal={Journal of gastroenterology and hepatology},
  year={1996},
  volume={11 2},
  pages={159-65}
}
To virologically assess the efficacy of interferon therapy in chronic hepatitis C, either 5 or 10 MU/day natural interferon-alpha (IFN alpha) was administered to 57 patients with chronic hepatitis C for 38 weeks. A complete and sustained response (CR-SR), as evidenced by the absence of serum hepatitis C virus (HCV)-RNA during the administration period and… CONTINUE READING