Long-term administration of cocaine or serotonin reuptake inhibitors results in anatomical and neurochemical changes in noradrenergic, dopaminergic, and serotonin pathways.

@article{Horne2008LongtermAO,
  title={Long-term administration of cocaine or serotonin reuptake inhibitors results in anatomical and neurochemical changes in noradrenergic, dopaminergic, and serotonin pathways.},
  author={Malcolm K. Horne and Joohyung Lee and Feng Chen and Katherine Lanning and Doris Tomas and Andrew J Lawrence},
  journal={Journal of neurochemistry},
  year={2008},
  volume={106 4},
  pages={1731-44}
}
The catechol and indole pathways are important components underlying plasticity in the frontal cortex and basal ganglia. This study demonstrates that administering rats either cocaine or a selective serotonin (or 5-hydroxytryptamine; 5-HT) reuptake inhibitor (SSRI) for 16 weeks results in reduced density of dopaminergic and noradrenergic terminals in the striatum and olfactory bulb, respectively, reflecting pruning of the terminal arbor of ventral midbrain dopaminergic and locus coeruleus… CONTINUE READING
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