Long-term administration of "sho-saiko-to" increases cytochrome P-450 mRNA level in mouse liver.

@article{Kojima1998LongtermAO,
  title={Long-term administration of "sho-saiko-to" increases cytochrome P-450 mRNA level in mouse liver.},
  author={Kazuo Kojima and Hajime Mizukami and Takako Tazawa and Mitsuhiko Nose and Miyuki Inoue and Yukio Ogihara},
  journal={Biological & pharmaceutical bulletin},
  year={1998},
  volume={21 4},
  pages={426-8}
}
Simplified differential display of mRNA was applied to isolate and identify genes transcriptionally regulated in mouse liver by sho-saiko-to administration. A cDNA fragment up-regulated by sho-saiko-to was isolated and characterized. cDNA sequencing and subsequent database analysis revealed that the fragment showed significant sequence similarity with mouse testosterone 16-alpha-hydroxylase (cytochrome P-450[16alpha]) cDNA. The increased level of mRNA expression of cytochrome P-450(16alpha) in… CONTINUE READING

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