Long-term adjunctive lacosamide treatment in patients with partial-onset seizures.

@article{Rosenow2016LongtermAL,
  title={Long-term adjunctive lacosamide treatment in patients with partial-onset seizures.},
  author={F. Rosenow and A. M. Kelemen and Elinor Ben-Menachem and Cindy McShea and Jouko Isojarvi and Pamela Doty},
  journal={Acta neurologica Scandinavica},
  year={2016},
  volume={133 2},
  pages={
          136-144
        }
}
OBJECTIVE To evaluate long-term (up to 5.5 years) safety, seizure reduction, and maintenance of efficacy of the antiepileptic drug (AED) lacosamide as adjunctive treatment in an open-label extension trial (SP774; ClinicalTrials.gov: NCT00515619). METHODS Three hundred and seventy-six adults with partial-onset seizures taking 1-3 AEDs enrolled following completion of a double-blind trial of adjunctive lacosamide. During open-label treatment, dosage of lacosamide (100-800 mg/day) and/or… CONTINUE READING