Long-term adaptation to high doses of morphine causes desensitization of mu-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits.

@article{Bourov2010LongtermAT,
  title={Long-term adaptation to high doses of morphine causes desensitization of mu-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits.},
  author={Lenka Bourov{\'a} and Miroslava Vo{\vs}ahl{\'i}kov{\'a} and Dmytro Kagan and Kateřina Dlouh{\'a} and Jir{\'i} Novotn{\'y} and Petr Svoboda},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2010},
  volume={16 8},
  pages={BR260-70}
}
BACKGROUND The functional activity of trimeric guanine-nucleotide-binding proteins (G-proteins) represents an essential step in linking and regulation of the opioid receptor (mu-, delta- and kappa-OR)-initiated signaling pathways. Theoretical basis and/or molecular mechanism(s) of opioid tolerance and addiction proceeding in the central nervous system were not studied in the forebrain cortex of mammals with respect to quantitative analysis of opioid-stimulated trimeric G-protein activity… CONTINUE READING