Long-term action of lithium: a role for transcriptional and posttranscriptional factors regulated by protein kinase C.

@article{Manji1994LongtermAO,
  title={Long-term action of lithium: a role for transcriptional and posttranscriptional factors regulated by protein kinase C.},
  author={Husseini K. Manji and Robert H. Lenox},
  journal={Synapse},
  year={1994},
  volume={16 1},
  pages={11-28}
}
Lithium, a simple monovalent cation, represents one of psychiatry's most important treatments and is the most effective treatment for reducing both the frequency and severity of recurrent affective episodes. Despite extensive research, the underlying biologic basis for the therapeutic efficacy this drug remains unknown, and in recent years, research has focused on signal transduction pathways to explain lithium's efficacy in treating both poles of manic-depressive illness. Critical to… CONTINUE READING
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