Long-term Visna virus infection of sheep choroid plexus cells: initiation and preliminary characterization of the carrier cultures.

@article{Trowbridge1975LongtermVV,
  title={Long-term Visna virus infection of sheep choroid plexus cells: initiation and preliminary characterization of the carrier cultures.},
  author={Richard S. Trowbridge},
  journal={Infection and immunity},
  year={1975},
  volume={11 4},
  pages={862-8}
}
Two sheep choroid plexus cell cultures were maintained and propagated for 413 days since being infected with strain K796 visna virus. The majority of the cells in these cultures contained visna virus-specific antigen on days 93 and 105 after infection. Reverse transcriptase-like activity similar to that present in visna virus preparations was obtained from these cultures when very little plaque-forming virus was being synthesized. The persistently infected cultures are resistant to the… CONTINUE READING