Long-term Potentiation in the Striatum is Unmasked by Removing the Voltage-dependent Magnesium Block of NMDA Receptor Channels.

@article{Calabresi1992LongtermPI,
  title={Long-term Potentiation in the Striatum is Unmasked by Removing the Voltage-dependent Magnesium Block of NMDA Receptor Channels.},
  author={Paolo Calabresi and Antonio Pisani and Nicola Biagio Mercuri and Giorgio Bernardi},
  journal={The European journal of neuroscience},
  year={1992},
  volume={4 10},
  pages={929-935}
}
We have studied the effects of tetanic stimulation of the corticostriatal pathway on the amplitude of striatal excitatory synaptic potentials. Recordings were obtained from a corticostriatal slice preparation by utilizing both extracellular and intracellular techniques. Under the control condition (1.2 mM external Mg2+), excitatory postsynaptic potentials (EPSPs) evoked by cortical stimulation were reversibly blocked by 10 microM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), an antagonist of dl… CONTINUE READING
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