Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease.

@article{Byers2013LongtermIE,
  title={Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease.},
  author={D. Byers and Jennifer Alexander-Brett and A. Patel and E. Agapov and Geoffrey Dang-Vu and X. Jin and Kangyun Wu and Yingjian You and Y. Alevy and J. Girard and T. Stappenbeck and G. Patterson and R. Pierce and S. Brody and M. Holtzman},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 9},
  pages={
          3967-82
        }
}
Chronic obstructive lung disease is characterized by persistent abnormalities in epithelial and immune cell function that are driven, at least in part, by infection. Analysis of parainfluenza virus infection in mice revealed an unexpected role for innate immune cells in IL-13-dependent chronic lung disease, but the upstream driver for the immune axis in this model and in humans with similar disease was undefined. We demonstrate here that lung levels of IL-33 are selectively increased in… Expand
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