Long-term EGF/serum-treated human thyrocytes mimic papillary thyroid carcinomas with regard to gene expression.

@article{Hebrant2007LongtermEH,
  title={Long-term EGF/serum-treated human thyrocytes mimic papillary thyroid carcinomas with regard to gene expression.},
  author={Aline Hebrant and Wilma C. G. van Staveren and Laurent Delys and David Y. Weiss Sol{\'i}s and Tatiana I Bogdanova and Guy Andry and Pierre P Roger and Jacques E. Dumont and Fr{\'e}d{\'e}rick Libert and C. Maenhaut},
  journal={Experimental cell research},
  year={2007},
  volume={313 15},
  pages={3276-84}
}
Constitutive activation of the RAS/RAF/MAPK pathway has been found in different tumor types including papillary thyroid carcinomas (PTCs). To get more insight into genes primarily regulated in the human tumor cells, an in vitro model was developed in which primary cultures of human thyrocytes were treated for different times with epidermal growth factor and serum (EGF/serum), which stimulate the MAPK cascade. Gene expression profiles were obtained by microarrays and compared to the expression… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…