Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight.

@article{Matson1999LongtermCS,
  title={Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight.},
  author={Claire A. Matson and Robert C. Ritter},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={1999},
  volume={276 4},
  pages={R1038-R1045}
}
The gut peptide CCK is a nutrient-related signal important to the control of food intake. In the present studies, we observed that a single intraperitoneal injection of CCK (1-2 μg/kg) given 2-3 h after intracerebroventricular leptin (2-5 μg) reduced body weight and chow intake over the ensuing 48 h more than did leptin alone. CCK alone had no effect on either 48-h chow intake or body weight but significantly reduced feeding during a 30-min sucrose test. However, reduction of 30-min sucrose… CONTINUE READING

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