Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults

  title={Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid $\beta$-42 and $\alpha$-Synuclein in Children and Young Adults},
  author={Lilian Calder{\'o}n-Garcidue{\~n}as and Anna C Solt and Carlos F. Henr{\'i}quez-Rold{\'a}n and Ricardo Torres‐Jard{\'o}n and Bryan L. Nuse and Lou A. Herritt and Rafael Villarreal-Calder{\'o}n and Norma Osnaya and Ida M. Stone and Raquel Garc{\'i}a and Diane M. Brooks and Ang{\'e}lica G{\'o}nzalez‐Maciel and Rafael Reynoso-Robles and Ricardo Delgado-Ch{\'a}vez and William Reed},
  journal={Toxicologic Pathology},
  pages={289 - 310}
Air pollution is a serious environmental problem. We investigated whether residency in cities with high air pollution is associated with neuroinflammation/neurodegeneration in healthy children and young adults who died suddenly. We measured mRNA cyclooxygenase-2, interleukin-1β, and CD14 in target brain regions from low (n = 12) or highly exposed residents (n = 35) aged 25.1 ± 1.5 years. Upregulation of cyclooxygenase-2, interleukin-1β, and CD14 in olfactory bulb, frontal cortex, substantia… 

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